The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination
نویسندگان
چکیده
منابع مشابه
Double-strand break repair and homologous recombination in Schizosaccharomyces pombe.
The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break r...
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Homologous recombination (HR) provides an important mechanism to repair both accidental and programmed DNA double-strand breaks (DSBs) during mitosis and meiosis. Defects in HR are associated with mutagenesis and predispose to cancer, highlighting the importance of this pathway for preserving genome integrity (Moynahan and Jasin, 2010). HR is active in the S and G2 phases of the cell cycle wher...
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Synapsis is the process by which paired chromosome homologues closely associate in meiosis before crossover. In the synaptonemal complex (SC), axial elements of each homologue connect through molecules of SYCP1 to the central element, which contains the proteins SYCE1 and -2. We have derived mice lacking SYCE2 protein, producing males and females in which meiotic chromosomes align and axes form...
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In fission yeast, the Swi5-Sfr1 complex plays an important role in homologous recombination (HR), a pathway crucial for the maintenance of genomic integrity. Here we identify and characterize mammalian Swi5 and Sfr1 homologues. Mouse Swi5 and Sfr1 are nuclear proteins that form a complex in vivo and in vitro. Swi5 interacts in vitro with Rad51, the DNA strand-exchange protein which functions du...
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The repair of DNA double-strand breaks (DSBs) is mediated via two major pathways, nonhomologous end joining (NHEJ) and homologous recombination (HR) repair. DSB repair is vital for cell survival, genome stability, and tumor suppression. In contrast to NHEJ, HR relies on extensive homology and templated DNA synthesis to restore the sequence surrounding the break site. We report a new role for th...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2011
ISSN: 0270-7306
DOI: 10.1128/mcb.05058-11